Table 2.

Use of HFNC in children with asthma.

Reference	Study design	Study Population	Comparison	Main Results
Baudin et al. [20]	Retrospective observational study	73 PICU patients aged 1 to 18 years with severe asthma	HFNC vs. COT	Lower heart, better respiratory rates and blood gas in the first 24 h in the HFNC group
Martinez et al. [21]	Observational study	536 children aged 4–5 years with moderate-to-severe asthma exacerbation	HFNC vs. COT	Lower PICU admissions in the HFNC group
Ballestero et al. [22]	Randomized pilot trial	62 children aged 1 to 14 years with asthma exacerbation	HFNC vs. COT	Improvement in respiratory dynamics after two hours in the HFNC group compared with the COT group

COT, conventional oxygen therapy; HFNC, high flow nasal cannula; PICU, pediatric intensive care unit.