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. 2022 Sep 23;10(10):2374. doi: 10.3390/biomedicines10102374

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Bar graphs showing mean ± standard error of insulin receptor mRNA in total kidney extracts that were obtained in separated experiments from Wistar-Kyoto (WKY) and Spontaneously Hypertensive (SHR) rats; Dahl salt-resistant (DSR) and Dahl salt-sensitive (DSS) rats; Control (CTR); and Fructose-fed (FFR) rats. Rats were fed low-sodium (shaded bars) or high-sodium (black bars) diets for 2 weeks. Optical density was determined on Northern blots and is expressed as scanner units normalized for 28S ribosomal RNA. In WKY and Control rats, the high-sodium diet induced a significant decrease in insulin receptor gene expression that was not found in SHR and FFR rats.