Figure 15.

H₂O₂ detoxification in TTase^+/+, TTase^−/−, and pure TTase enzyme loaded TTase^−/− mouse LECs. ROS fluorescence was measured by fluorescence-activated cell sorter (FACS). The H₂O₂ (50 μM) treatment time course of the mean DCF fluorescence intensity was followed for TTase^+/+ (■), TTase-loaded TTase^−/− (O), and TTase^−/− (●). Error bars indicate SD, n = 5. * Significant difference from the TTase^+/+ and TTase-loaded TTase^−/− cells (p < 0.05). Reprinted with permission from Lofgren et al., IOVS (2008); Copyright ARVO 2008 [109].