Table 2.
LiMAx® values and parameters of hepatocellular damage, cholestasis and synthesis in sepsis and septic shock.
| Parameter | Point of Measurement | Sepsis | Septic Shock | Sepsis vs. Septic Shock p-Value |
Sepsis p-Value |
Septic Shock p-Value |
|
|---|---|---|---|---|---|---|---|
|
LiMAx® (µg/kg/h) |
Preadsorber | T1 | 166.43 ± 99.53 * (97.5–224) |
117.36 ± 73.76 * (60–176) |
0.276 | ||
| Hemoadsorption (CytoSorb®) | T2 | 109.43 ± 43.95 * (84.5–126) |
64.86 ± 40.62 * (29.75–102.75) |
0.046 | 0.148 | 0.003 # | |
| T3 | 130.86 ± 66.12 * (92.5–167.5) |
98.14 ± 68.66 * (52.25–129.75) |
0.311 | 0.261 | 0.025 | ||
| Postadsorber | T4 | 221.43 ± 40.95 * (207–240.5) |
188.36 ± 120.09 * (125.25–274.25) |
0.366 | 0.003 # | 0.001 # | |
|
ALT (U/L) (Reference range < 50) |
Preadsorber | T1 | 34 * (16.5–53) |
33.5 (15.25–161) |
0.502 | ||
| Hemoadsorption (CytoSorb®) | T2 | 25 * (19–33) |
48 (14.25–403.25) |
0.412 | 0.208 | 0.195 | |
| T3 | 21 * (16–28) |
58.5 (16.75–246.75) |
0.117 | 0.025 | 0.03 | ||
| Postadsorber | T4 | 21 * (16.5–30.5) |
34 (13.25–181.25) |
0.654 | 0.593 | 0.055 | |
|
Alkaline Phosphatase (U/L) (Reference range: 40–129) |
Preadsorber | T1 | 64 (50–66) |
101 * (65.5–145) |
0.073 | ||
| Hemoadsorption (CytoSorb®) | T2 | 59 (54.5–64.5) |
88 (70.25–110.5) |
0.062 | 1 | 0.124 | |
| T3 | 76 * (59–97) |
109 * (73.75–141.5) |
0.156 | 0.059 | 0.028 | ||
| Postadsorber | T4 | 121 * (81.5–166.5) |
147.5 (80.25–202) |
0.765 | 0.034 | 0.019 | |
|
Bilirubin (mg/dL) (Reference range: <1.2) |
Preadsorber | T1 | 0.43 * (0.35–0.87) |
0.51 (0.47–0.63) |
0.737 | ||
| Hemoadsorption (CytoSorb®) | T2 | 0.48 * (0.25–0.64) |
0.45 (0.37–0.94) |
0.391 | 0.02 | 0.326 | |
| T3 | 0.36 * (0.24–0.42) |
0.56 * (0.42–0.69) |
0.015 | 0.248 | 0.51 | ||
| Postadsorber | T4 | 0.37 * (0.29–0.42) |
0.62 * (0.46–1.04) |
0.037 | 0.537 | 0.091 | |
| INR | Preadsorber | T1 | 1.24 * (1.21–1.32) |
1.28 (1.19–1.45) |
0.55 | ||
| Hemoadsorption (CytoSorb®) | T2 | 1.38 * (1.33–1.48) |
1.61 * (1.45–1.72) |
0.062 | 0.0002 # | 0.006# | |
| T3 | 1.40 * (1.25–1.44) |
1.37 * (1.24–1.57) |
0.654 | 0.203 | 0.03 | ||
| Postadsorber | T4 | 1.04 * (1.00–1.08) |
1.22 * (1.07–1.29) |
0.04 | 0.002 | 0.018 | |
Sepsis vs. Septic Shock: Data presented as median (IQR), exception LiMAx®: Mean ± SD (normal distribution at all times of measurement),*: Normal distribution; #: Significant p-value: p < 0.0125. Sepsis and Septic Shock: Sliding baseline (comparison T1–2; T2–3 and T3–4); Data presented as median (IQR), exception LiMAx®: Mean ± SD (normal distribution at all times of measurement),*: Normal distribution; #: Significant p-value: p < 0.0167.