Table 3.
Hepatic impairment or liver failure in sepsis and septic shock.
| Parameter | Point of Measurement | Sepsis | Septic Shock | |
|---|---|---|---|---|
| LiMAx® | Preadsorber | T1 | 3 (43%) | 5 (36%) |
| Impaired liver function | Hemoadsorption (CytoSorb®) | T2 | 1 (14%) | 0 (0%) |
| (314–140 µg/kg/h) | T3 | 2 (28%) | 3 (21%) | |
| Postadsorber | T4 | 7 (100%) | 5 (36%) | |
| LiMAx® | Preadsorber | T1 | 3 (43%) | 9 (64%) |
| Severe liver damage | Hemoadsorption (CytoSorb®) | T2 | 6 (86%) | 14 (100%) |
| (0–139 µg/kg/h) | T3 | 5 (71%) | 11 (79%) | |
| Postadsorber | T4 | 0 (0%) | 7 (50%) | |
| Elevated ALT | Preadsorber | T1 | 2 (29%) | 6 (43%) |
| (≥50 U/L) | Hemoadsorption (CytoSorb®) | T2 | 1 (14%) | 7 (50%) |
| T3 | 0 (0%) | 7 (50%) | ||
| Postadsorber | T4 | 1 (14%) | 5 (36%) | |
| Elevated alkaline phosphatase | Preadsorber | T1 | 1 (14%) | 5 (36%) |
| (≥129 U/L) | Hemoadsorption (CytoSorb®) | T2 | 1 (14%) | 3 (21%) |
| T3 | 1 (14%) | 4 (29%) | ||
| Postadsorber | T4 | 3 (43%) | 8 (57%) | |
| Hyperbilirubinemia | Preadsorber | T1 | 0 (0%) | 3 (21%) |
| (≥1.2 mg/dL) | Hemoadsorption (CytoSorb®) | T2 | 0 (0%) | 3 (21%) |
| T3 | 0 (0%) | 0 (0%) | ||
| Postadsorber | T4 | 0 (0%) | 3 (21%) | |
|
INR (≥1.5) |
Preadsorber | T1 | 0 (0%) | 3 (21%) |
| Hemoadsorption (CytoSorb®) | T2 | 2 (29%) | 10 (71%) | |
| T3 | 1 (14%) | 6 (43%) | ||
| Postadsorber | T4 | 0 (0%) | 2 (14%) | |
Legend: total number and percentage (%) of patients.