Table 4.
Parameter of inflammation and shock reversal in sepsis and septic shock.
| Parameter | Point of Measurement | Sepsis | Septic Shock | Sepsis vs. Septic Shock p-Value | Sepsis p-Value |
Septic Shock p-Value | |
|---|---|---|---|---|---|---|---|
|
Interleukin-6 (pg/mL) (Reference range: <7) |
Preadsorber | T1 | 1402 (727.75–5317) |
4713 (1089.5–11717.5) |
0.443 | ||
| Hemoadsorption (CytoSorb®) | T2 | 374.20 (175.15–553.2) |
448.35 (135.75–2593.25) |
0.743 | 0.016 # | 0.0004 # | |
| T3 | 210.4 * (97.15–263.90)) |
329.4 (107.68–668.33) |
0.287 | 0.156 | 0.091 | ||
| Postadsorber | T4 | 68.30 (27.35–139.80) |
128.75 (57.58–446.38) |
0.094 | 0.375 | 0.042 | |
|
Norepinephrine dose (µg/kg/min) |
Preadsorber | T1 | 0.09 * (0.07–0.19) |
0.22 * (0.11–0.65) |
0.19 | ||
| Hemoadsorption (CytoSorb®) | T2 | 0.24 * (0.14–0.37) |
0.56 * (0.43–0.73) |
0.007 # | 0.09 | 0.005 # | |
| T3 | 0.09 * (0.05–0.10) |
0.16 (0.11–0.19) |
0.038 | 0.016 # | 0.0001 # | ||
| Postadsorber | T4 | 0.05 * (0.02–0.09) |
0.05 (0.02–0.08) |
0.97 | 0.721 | 0.0006 # | |
Sepsis vs. Septic Shock: data presented as median (IQR), *: normal distribution; #: significant p-value p < 0.0125 Sepsis and Septic Shock: sliding baseline (comparison T1–2; T2–3 and T3–4); data presented as median (IQR); *: normal distribution; #: significant p-value: p < 0.0167.