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. 2022 Oct 9;11(10):1380. doi: 10.3390/antibiotics11101380

Figure 6.

Figure 6

Biosynthesis pathway of alkaloid antimicrobial agent (-)-colchicine. GsPAL, phenylalanine ammonia-lyase; GsCCR, cinnamoyl-CoA reductase; GsAER, alkenal reductase; GsC4H, cinnamate 4-hydroxylase; GsTyDC/DDC, L-tyrosine/L-DOPA decarboxylase; BvCYP76AD5, cytochromes P450 3′-hydroxylase; CjNCS, (S)-norcoclaurine synthase; S-adenosylmethionine-dependent methyltransferase (MT): GsOMT1, GsOMT2, GsOMT3, GsOMT4, O-methyltransferase; GsNMT1, N-methyltransferase; GsCYP75A109, GsCYP75A110, GsCYP71FB1, GsCYP71DA12, cytochromes P450; GsABH1, alpha/beta hydrolase; GsNAT1, N-acetyltransferase.