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Underlying mechanisms involved in phlorizin-induced longevity. Lifespans of known long-lived mutants, age-1 (A), clk-1 (B), and eat-2 (C), were monitored with or without supplementation with phlorizin. (D) Effect of phlorizin on lifespan was examined when expression of daf-16 or bec-1 was repressed by RNAi. PZ, phlorizin (10 μM); EV, empty vector.
