Figure 1.

Expression of NADPH oxidases in different cell types that form the BBB. The BBB is formed by capillary brain endothelial cells surrounded by basal lamina, pericytes and astrocytic perivascular endfeet. Brain capillaries are also surrounded by microglial cells and neuronal processes. Nox1 and 2 have been described in endothelial cells, astrocytes, neurons and microglial cells. Nox4 has been described in endothelial cells, astrocytes, neurons, microglial cells and pericytes. Nox3, in contrast, has only been described in neurons and Nox5 in brain endothelial cells.