Table 2.
Serum biomarkers in patients with COVID-19 according to the severity of infection.
| Non-Severe COVID-19 | Severe COVID-19 | p-Value | |
|---|---|---|---|
| Day 1 | |||
| TNFα, pg/mL | 19.2 (16–24.7) | 23.6 (19.7–29) | <0.001 |
| Angiopoietin2, pg/mL | 1548 (1108–2268) | 1477 (1043–2213) | 0.577 |
| IL-1β, pg/mL | 17.3 (10.8–22.8) | 24.7 (16–29.1) | <0.001 |
| Pentraxin, pg/mL | 5213 (27,430–8301) | 8781 (5091–12,744) | <0.001 |
| Resistin, pg/mL | 17,961 (13,593–28,441) | 23,098 (15,761–31,369) | 0.032 |
| Chemerin, pg/mL | 8774 (3228) | 9183 (4277) | 0.396 |
| Adiponectin, ng/mL | 8536 (5374–54,126) | 5384 (4361–8387) | <0.001 |
| Leptin, pg/mL | 1578 (885–3546) | 2343 (1092–4235) | 0.091 |
| Day 7 | |||
| TNFα, pg/mL | 21.3 (17.3–26.2) | 25.5 (21.5–28.9) | <0.001 |
| Angiopoietin2, pg/mL | 1246 (899–1764) | 1260 (911–1598) | 0.547 |
| IL-1β, pg/mL | 17.9 (14.1–25.2) | 26.1 (20.4–30.2) | <0.001 |
| Pentraxin3, pg/mL | 3080 (1928–4890) | 3443 (2563–5157) | 0.095 |
| Resistin, pg/mL | 16,635 (7866) | 17,984 (9060) | 0.212 |
| Chemerin, pg/mL | 7256 (5607–9511) | 7394 (5747–9603) | 0.565 |
| Adiponectin, ng/mL | 7977 (5714–47,591) | 6308 (4839–9285) | <0.001 |
| Leptin, pg/mL | 1461 (745–2988) | 1702 (981–3438) | 0.101 |
| Day 28 | |||
| TNFα, pg/mL | 18.7 (15.2–22.2) | 20.5 (17.5–24) | 0.002 |
| Angiopoietin2, pg/mL | 1662 (1156–2105) | 1662 (1174–2134) | 0.877 |
| IL-1β, pg/mL | 16 (10.8–21.2) | 2..4 (14.9–26.8) | <0.001 |
| Pentraxin3, pg/mL | 1707 (1044–2353) | 1954 (1191–2785) | 0.130 |
| Resistin, pg/mL | 11,609 (8632–15,307) | 11,740 (8339–15,999) | 0.951 |
| Chemerin, pg/mL | 9171 (7345–10,594) | 9618 (7490–11,310) | 0.252 |
| Adiponectin, ng/mL | 11,693 (6698–62,374) | 7283 (5674–10,450) | <0.001 |
| Leptin, pg/mL | 1263 (755–2168) | 1452 (847–3006) | 0.194 |
The results are shown as means (SD) or medians (IQR). TNFα, tumor necrosis factor alfa; Il-1β, interleukin 1 beta; COVID-19, coronavirus disease 2019.