Table 3.
Toxicity report predicted by Pro Tox-II web-server for EB367.
| Classification | Target | Prediction | Probability |
|---|---|---|---|
| Organ toxicity | Hepatotoxicity | Inactive | 0.65 |
| Toxicity end points | Carcinogenicity | Inactive | 0.62 |
| Immunotoxicity | Active | 0.89 | |
| Mutagenicity | Inactive | 0.72 | |
| Cytotoxicity | Inactive | 0.78 | |
| Tox21-Nuclear receptor signaling pathways | Aryl hydrocarbon Receptor (AhR) | Inactive | 0.84 |
| Androgen Receptor (AR) | Inactive | 0.84 | |
| Androgen Receptor Ligand Binding Domain (AR-LBD) | Inactive | 0.78 | |
| Aromatase | Inactive | 0.82 | |
| Estrogen Receptor Alpha (ER) | Inactive | 0.73 | |
| Estrogen Receptor Ligand Binding Domain (ER-LBD) | Inactive | 0.88 | |
| Peroxisome Proliferator Activated Receptor Gamma (PPAR-Gamma) | Inactive | 0.92 | |
| Tox21-Stress response pathways | Nuclear factor (erythroid-derived 2)-like 2/antioxidant responsive element (nrf2/ARE) | Inactive | 0.88 |
| Heat shock factor response element (HSE) | Inactive | 0.88 | |
| Mitochondrial Membrane Potential (MMP) | Inactive | 0.68 | |
| Phosphoprotein (Tumor Supressor) p53 | Inactive | 0.79 | |
| ATPase family AAA domain-containing protein 5 (ATAD5) | Inactive | 0.94 |
(Tox21) Toxicology in the 21st Century program [71].