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. 2022 Oct 20;12(10):1524. doi: 10.3390/biom12101524

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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SMN granules are spatially associated with MAP1B at presynaptic motor terminals. (A). SMN granules (magenta) follow the MAP1B trajectory (green) in control mice, both in the axon and the presynaptic terminal. MAP1B can form rounded structures containing organized SMN granules (inset) at the most distal portions of the intraterminal branches. The linear intensity profile of MAP1B (green) and SMN (magenta) in segments 1 and 2 in the images are shown in the lower graphs. (B). In SMA mice, MAP1B has a diffuse appearance. Linear intensity profile of MAP1B (green) and SMN (magenta) in segments 1 and 2 indicated in lower graphs. Note that the MAP1B signal encompasses the SMN signal. Scale bars: 10 μm.