Table 3.
Curcumin modulates circRNAs in various cancers.
| In Vitro/ In Vivo |
Cell Line | Modulated by Curcumin | Relevant Mechanism | Biological Effects after Administration | Refs. |
|---|---|---|---|---|---|
| In vitro/ In vivo |
H1650, H1299, H460, A549, 16HBE (NSCLC) | circ-PRKCA ↓ | circ-PRKCA/miR-384/ITGB1 pathway | Inhibits viability, colony formation, migration, invasion, promotes apoptosis | [130] |
| In vitro/ In vivo |
THLE-2, HuH-7, HCCLM3 (HCC) | circ-ZNF83 ↓ | JAK2/STAT3 pathway circZNF83/miR-324-5p/CDK16 axis | Inhibits proliferation, cell cycle, migration, invasion, promotes apoptosis | [131] |
| In vitro/ In vivo |
SKOV3, A2780, IOSE-80 (Ovarian cancer) |
circ-PLEKHM3 ↑ | circ-PLEKHM3/miR-320a/SMG1 axis | Inhibits proliferation and promotes apoptosis | [132] |
| In vitro/ In vivo |
CAKI-1, ACHN, (RCC) |
circ-FNDC3B ↓ | circ-FNDC3B/miR-138-5p/IGF2 axis | Inhibits proliferation, promotes apoptosis | [133] |
| In vitro | CNE-2 (NPC) | circRNA-102115 | circRNA-102115/miR-335-3p/MAPK1 | Enhances radiosensitization | [113] |
| In vitro | CNE-2 (NPC) | circRNA network | miRNA sponge regulated EGFR, STAT3, GRB2 | Enhances radiosensitization | [134] [135] |
Note: Arrows “↓, ↑” represent the expression levels of circRNAs regulated by curcumin in various cancers. “↑”: upregulated, “↓”: downregulated.