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Schematic diagram of the formation process of different linkers between drugs and PAMAM. Different background colors represent the synthesis of linkers with different release properties: pink for acid-sensitive, blue for non-acid-sensitive and purple for GSH-sensitive. DOX is taken as an example of a drug. DOX: doxorubicin; BMPH: N-(β-maleimidopropionic acid) hydrazide; SPDP: N-succinimidyl-3-(2-pyridyldithio) proprionate.
