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. 2022 Oct 11;14(20):4983. doi: 10.3390/cancers14204983

Figure 5.

Figure 5

Knock-down of either component of the TIMP-1/CD63/ITGB1/STAT3 loop prevents CAF-CM-raised migration and affects cellular growth in 2D cultures. (A) Wound-healing assays of AnD5 cells transfected with an siRNA as indicated in the absence (blue line) or presence of CAF-CM (red line). (B,C) Growth assays in 2D adherent (B) and in 3D suspension cultures (C) in the presence of CAF-CM and/or FULV after AnD5 cells have been transfected with one of the five siRNAs as indicated. (A–C) Each bar represents the mean value ± S.D. (N ≥ 3). Statistical analyses were performed using Anova. Asterisks denote p-values: * p < 0.05, ** p < 0.01, *** p < 0.005, **** p < 0.001.