Table 1.
List of GPCRs that signal from intracellular compartments.
| Subcellular Localization | Receptor | Reference |
|---|---|---|
| Early endosomes | β2-adrenergic receptor (β2AR) | [26] |
| Calcitonin-gene-related-peptide receptor (CGRPR) | [27] | |
| Calcium-sensing receptor (CaSR) | [28] | |
| Dopamine receptor type 1 (D1R) | [29] | |
| Luteinizing hormone receptor (LHR) | [30] | |
| Neurokinin type 1 receptor (NK1R) | [31] | |
| Parathyroid hormone receptor (PTHR) | [32] | |
| Protease activated receptor 2 (PAR2) | [33] | |
| Vasopressin type 2 receptor (V2R) | [34] | |
| Nucleus | α1A-adrenergic receptor (α1A-AR) | [35] |
| α1B-adrenergic receptor (α1B-AR) | [35] | |
| Adenosine A1 receptor (ADORA1) | [36] | |
| Adenosine A2B (ADORA2B) | [36] | |
| Angiotensin AT1A receptor (AT1AR) | [37] | |
| Apelin receptor (APJ) | [38] | |
| Bradykinin B2 receptor (BKR2) | [38] | |
| Cysteine (C)-x-C receptor 4 (CXCR4) | [39] | |
| Oxytocin receptors (OXTR) | [40] | |
| C-C chemokine receptor type 2 (CCR2) | [41] | |
| Arginine vasopressin receptor 1α (AVPR1a) | [41] | |
| Sphingosine 1-phosphate receptor 1(S1P1) | [41] | |
| Mitochondria | Purinoceptor 1 like receptor (P2Y1) | [42] |
| Purinoceptor 2 like receptor (P2Y2) | [42] | |
| Angiotensin II receptor type 1 (AT1R) | [43] | |
| Angiotensin II receptor type 2 (AT2R) | [43] | |
| 5-hydroxytrptamine receptor (5-HTR3 and 5-HTR4) | [44] | |
| Melatonin MT1 receptor (MT1R) | [45] | |
| Cannabinoid type 1 receptor 1 (CB1R) | [46] | |
| Golgi | β1-adrenergic receptor (β1AR) | [47] |
| Sphingosine-1-phosphate 1 receptor (S1P1R) | [48] | |
| Thyroid stimulating hormone receptor (TSHR) | [49] | |
| ER | G Protein-Coupled Estrogen Receptor 1 (GPR30) | [50] |
| Metabotropic glutamate receptor 5 (mGluR5) | [25] | |
| Exosomes | G Protein-Coupled Receptor Class C Group 5 Member B (GPRC5B) | [51] |
| Spindle poles | Olfactory receptor 2A4 (OR2A4) | [24] |