Table 2.
Cox proportional-hazard regression analysis for different characteristics in ESCC patients.
| Characteristics | Univariate Analysis | Multivariate Analysis | ||||
|---|---|---|---|---|---|---|
| Hazard Ratio | 95% CI | p-Value | Hazard Ratio | 95% CI | p-Value | |
| Gender | ||||||
| Male | Reference | |||||
| Female | 0.14 | 0.02–1.00 | 5.01 × 10−2 | 0.35 | 0.03–4.00 | 4.02 × 10−1 |
| Age at diagnosis | 1.03 | 0.99–1.08 | 1.26 × 10−1 | 1.03 | 0.97–1.11 | 3.07 × 10−1 |
| Race | ||||||
| Asian | Reference | |||||
| White | 1.53 | 0.65–3.63 | 3.31 × 10−1 | 1.37 | 0.45–4.16 | 5.80 × 10−1 |
| Black (black or African American) | 3.05 | 0.81–11.44 | 9.89 × 10−2 | 0.18 | 0.01–3.20 | 2.40 × 10−1 |
| Tumor central location | ||||||
| Mid | Reference | |||||
| Distal | 0.81 | 0.38–1.74 | 5.92 × 10−1 | 1.51 | 0.53–4.28 | 4.36 × 10−1 |
| Proximal | 0 | 0–Inf | 9.98 × 10−1 | 0 | 0-Inf | 9.98 × 10−1 |
| Stage | ||||||
| I–II | Reference | |||||
| III–IV | 2.59 | 1.23–5.46 | 1.26 × 10−2 | 1.25 | 0.46–3.39 | 6.59 × 10−1 |
| Histologic grade | ||||||
| Grade 1 | Reference | |||||
| Grade 2 | 1.84 | 0.62–5.46 | 2.71 × 10−1 | 0.61 | 0.15–2.47 | 4.89 × 10−1 |
| Grade 3 | 0.93 | 0.23–3.71 | 9.13 × 10−1 | 0.24 | 0.05–1.20 | 8.24 × 10−2 |
| Alcohol consumption | ||||||
| Never | Reference | |||||
| Yes | 2.02 | 0.7–5.85 | 1.93 × 10−1 | 1.57 | 0.39–6.27 | 5.2 × 10−1 |
| Tobacco smoking history | ||||||
| Never | Reference | |||||
| Yes | 1.51 | 0.64–3.55 | 3.46 × 10−1 | 0.74 | 0.21–2.62 | 6.4 × 10−1 |
| Molecular types | ||||||
| Subtype 1 | Reference | |||||
| Subtype 2 | 13.53 | 3.85–47.57 | 4.91 × 10−5 | 51.60 | 3.99–667.48 | 2.5 × 10−3 |