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IFN-α-dependent STAT1 signaling is antagonized by lyssavirus P3 proteins. IFN-α-dependent signaling in NA cells expressing the indicated proteins was analyzed using a dual luciferase reporter gene assay. Luciferase activity is expressed as a fold change relative to that obtained for IFN-α-treated cells expressing GFP-N protein (mean relative luciferase activity ± standard deviation [SD]; n = 2 from 2 separate assays for +IFN-α samples).
