Figure 5.

Type I IFN receptor subunit 1 deficiency reduces aortic leukocyte accumulation in experimental AAAs. Aortic frozen sections from elastase-infused wild type (WT, n = 7) and type 1 IFN receptor subunit 1-deficient (IFNAR1^−/−, n = 12) mice were stained with monoclonal antibodies against CD68 for macrophages, CD4 for CD4⁺ T cells, CD8 for CD8⁺ T cells and B220 for B cells. Macrophage accumulation was scored from I (mild) to IV (severe). Other leukocytes were enumerated as positively stained cells/aortic cross-section (ACS). (A) Representative images for macrophages, CD4⁺ and CD8⁺ T cells and B cells in elastase-infused WT and IFNAR1^−/−mice. (B–E) Quantification (median and interquartile) of mural macrophages, CD4⁺ T cells, CD8⁺ T cells and B cells between groups. Nonparametric Mann–Whitney test, ** p < 0.01 compared to WT mice. Scale bar: 200 μm.