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. 2022 Oct 7;12(10):1438. doi: 10.3390/biom12101438

Figure 2.

Figure 2

Nrf2 and Keap1 structure. Nrf2 (A) is comprised of seven functional Neh domains. Neh2 is required for Keap1 dependent homeostatic regulation. Neh3, Neh4, and Neh5 are required for transactivation and facilitatory cofactor binding and Neh1 contains the DNA binding basic leucine zipper domain. Neh6 and Neh7 contain sites that allow redox independent Nrf2 inhibition. Keap1 (B) contains two major domains that are relevant to Nrf2-regulation. The broad complex, tramtrack and bric a brac (BTB) domain is required for formation of the Keap1 homodimer-Cul3 complex and the double glycine repeat (DGR) anchors Nrf2 and actin to maintain Nrf2s cytoplasmic localisation during steady state. Oxidation of cysteine residues located in the BTB and intervening region (IVR) result in conformational change that releases Nrf2. Adapted from Jaramillo and Zhang (2013) [132]. Created with BioRender.com.