Table 3.
The performance of [68Ga]Ga-PSMA-11 for BCR.
| Patients’ Condition | Treatment | Imaging Modality | Detection Rate (%) (PSA:ng/mL) |
Reference |
|---|---|---|---|---|
| Number of patients: 31 GSC: 7 (5–9) PSA (ng/mL): 2.0 (0.1–130.0) Mean age: 71 (51–78) |
The combination or single use of RT, RP, HDR brachytherapy, and ADT and HIFU | dPET/CT and whole-body PET/CT | Overall: 71 46.7 (PSA: 0.1–2) 75.0 (PSA: >2) |
[81] |
| Number of patients: 56 GSC: 6–9 (7/56 unknown) PSA (ng/mL): 0.99 (IQR: 3.1) Mean age: 69 (IQR: 11) |
RP | PET/MRI | Overall: 78.6 44.4 (PSA: <0.2); 72.7 (PSA: 0.2–0.5) 80.0 (PSA: 0.5–2.0) 95.2 (PSA: >2.0) |
[82] |
| Number of patients: 1007 GSC: 7 (5–10) PSA (ng/mL): 2.2 (0.01–1237) Mean age: 68 (39–90) |
The combination or single use of RP, RT, ADT and HIFU | PET/CT | Overall: 79.5 46 (PSA: ≤0.2); 46 (PSA: 0.21–0.5) 73 (PSA: 0.51–1.0) 80 (PSA: 1.1–2.0) 86 (PSA: 2.1–3.0) 91 (PSA: 3.1–5.0) 94 (PSA: 5.1–7.0) 91 (PSA: 7.1–10.0) 96 (PSA: >10.0) |
[76] |
| Number of patients: 270 GSC: ≥6 (6% unknown) PSA (ng/mL): 0.44 (0.03–1) Mean age: 68 (43–90) |
RP without RT | PET/CT | Overall: 49 | [83] |
| Number of patients: 119 GSC: ≥6 PSA (ng/mL): 0.32 (0.2–0.5) Mean age: 66 (44–78) |
RP without RT after recurrence | PET/CT | Overall: 34.4 | [84] |
| Number of patients: 223 PSA (ng/mL): 0.65 (0.2–8.9) Mean age: 70 (66–75) |
RT, ADT-free six months before PET scan | PET/CT | Overall: 39.9 23.2 (PSA: 0.2–0.5) 49.6 (PSA: >0.5) |
[78] |
| Number of patients: 660 GSC: >6, 45 patients GSC ≤ 6 PSA (ng/mL): median PSA 10.65 Mean age: 70 (49–88) |
RP, RT, or brachytherapy | PET/CT | Overall: 76 41 (PSA: <0.2) 44.7 (PSA: 0.2–0.5) 61.7 (PSA: 0.5–1.0) 72.3 (PSA: 1.0–2.0) 82.5 (PSA: 2.0–5.0) 94 (PSA: ≥5) |
[85] |
| Number of patients: 581 GSC: >6, 37 patients GSC ≤ 6 PSA (ng/mL): 2.98 (0.2–2000) Mean age: 71 (49–88) |
RP, RT, and ADT | PET/CT | Overall: 77 Overall Post-RP: 75 40 (PSA: 0.2–0.5) 62 (PSA: 0.5–1) 70 (PSA: 1–2) 84 (PSA: 2–5) 94 (PSA: ≥5) Overall p-RT: 9188 (PSA: 2–5) 93 (PSA: ≥5) |
[86] |
| Number of patients: 84 GSC: ≥8 PSA (ng/mL): 4.27 (0.8–18) Mean age: 71 (66–76) |
Prior therapy: RT or RP Ongoing therapy: ADT |
PET/CT or PET/MRI | Overall: 94 85.2 (PSA: 0–1) 97.3 (PSA: 1–20) 100 (PSA: >20) |
[87] |