Table 2.
Reactome analysis highlighting the 20 pathways with the lowest FDR, which are associated with upregulated mDEGs.
| Pathway Identifier | Pathway Name | Entities Found | FDR |
|---|---|---|---|
| R-HSA-198933 | Immunoregulatory interactions between a lymphoid and a non-lymphoid cell | 81 | 7.2839 × 10−31 |
| R-HSA-1474244 | Extracellular matrix organization | 109 | 2.4259 × 10−14 |
| R-HSA-380108 | Chemokine receptors bind chemokines | 35 | 1.4862 × 10−11 |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 106 | 2.2223 × 10−11 |
| R-HSA-202430 | Translocation of ZAP-70 to immunological synapse | 16 | 1.2195 × 10−9 |
| R-HSA-389948 | PD-1 signaling | 18 | 1.55 × 10−9 |
| R-HSA-6798695 | Neutrophil degranulation | 132 | 5.2463 × 10−9 |
| R-HSA-500792 | GPCR ligand binding | 126 | 5.25 × 10−9 |
| R-HSA-909733 | Interferon alpha/beta signaling | 33 | 5.2463 × 10−9 |
| R-HSA-202433 | Generation of second messenger molecules | 22 | 5.2463 × 10−9 |
| R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains | 17 | 5.2463 × 10−9 |
| R-HSA-1474228 | Degradation of the extracellular matrix | 55 | 1.2723 × 10−8 |
| R-HSA-877300 | Interferon gamma signaling | 40 | 3.5328 × 0−8 |
| R-HSA-1442490 | Collagen degradation | 32 | 6.6811 × 10−8 |
| R-HSA-375276 | Peptide ligand-binding receptors | 67 | 7.395 × 10−8 |
| R-HSA-6809371 | Formation of the cornified envelope | 50 | 8.368 × 10−8 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 44 | 1.1813 × 10−7 |
| R-HSA-6783783 | Interleukin-10 signaling | 25 | 2.22 × 10−7 |
| R-HSA-1474290 | Collagen formation | 37 | 7.0322 × 10−7 |
| R-HSA-418594 | G alpha (i) signaling events | 108 | 1.4245 × 10−6 |