Table 1.

Mitochondria-targeted therapies for UC.

Therapies	Strategies	Targets	References
DCA	inhibit PDK and activate PDH	mitochondrial TCA	[76]
vitamin K2	promote the glycolysis	mitochondrial TCA	[78]
AS-ODNs	improve drug sensitivity induce apoptosis	BCL-2, NRB1	[84,85]
siRNA	improve drug sensitivity induce apoptosis	BCL-2, NRB1	[66]
metformin	induce apoptosis	mitochondria	[77]
silibinin	induce apoptosis	mitochondria	[86]
baicalein	induce apoptosis	mitochondria	[100]
resveratrol	induce apoptosis	mitochondria	[104,105]
CXC195	induce apoptosis	TMP analog	[79]
TRAIL	induce apoptosis	mitochondria	[106]
UVA	damage mitochondria	mitochondria	[110]

AS-ODNs, antisense oligodeoxynucleotides; siRNA, small interfering RNA; TMP, tetramethylpyrazine; TRAIL, tumor necrosis factor (TNF)-related apoptosis-inducing ligand; DCA, dichloroacetate; PDK, pyruvate dehydrogenase kinase; PDH, pyruvate dehydrogenase; UVA, ultraviolet A.