Table 4.
Incidence rate and subhazard ratio of hip fracture in patients using antiplatelet agents employing competing risks regression models.
| Variables | cSHR (95% CI) | p-Value | aSHR (95% CI) | p-Value |
|---|---|---|---|---|
| Aspirin or clopidogrel | ||||
| Non-users | 1.00 (reference) | 1.00 (reference) | ||
| users | 1.67 (1.38, 2.03) | <0.001 | 0.90 (0.73, 1.11) | 0.320 |
| Aspirin or clopidogrel | ||||
| Non-users | 1.00 (reference) | 1.00 (reference) | ||
| Aspirin Monotherapy | 1.65 (1.34, 2.03) | <0.001 | 1.00 (0.81, 1.24) | 0.960 |
| Clopidogrel Monotherapy | 2.68 (1.49, 4.80) | <0.001 | 0.96 (0.53, 1.74) | 0.900 |
| Dual Therapy | 1.58 (1.14, 2.18) | 0.010 | 0.59 (0.42, 0.82) | <0.001 |
| Dose of aspirin | ||||
| <28 cDDD | 1.00 (reference) | 1.00 (reference) | ||
| 28–179 cDDD | 1.41 (1.12, 1.78) | <0.001 | 0.95 (0.75, 1.21) | 0.660 |
| 180–359 cDDD | 1.58 (1.13, 2.21) | 0.010 | 0.84 (0.60, 1.19) | 0.330 |
| >360 cDDD | 1.70 (1.32, 2.19) | <0.001 | 0.88 (0.67, 1.15) | 0.330 |
| Dose of clopidogrel | ||||
| <28 cDDD | 1.00 (reference) | 1.00 (reference) | ||
| 28–179 cDDD | 1.90 (1.26, 2.87) | <0.001 | 0.97 (0.64, 1.47) | 0.890 |
| 180–359 cDDD | 0.41 (0.13, 1.27) | 0.120 | 0.21 (0.07, 0.66) | 0.010 |
| >360 cDDD | 1.42 (0.93, 2.16) | 0.100 | 0.67 (0.44, 1.03) | 0.070 |
| Dose of dual agents | ||||
| <28 cDDD | 1.00 (reference) | 1.00 (reference) | ||
| 28–179 cDDD | 1.57 (1.24, 1.98) | <0.001 | 1.00 (0.79, 1.27) | 0.960 |
| 180–359 cDDD | 1.58 (1.11, 2.23) | 0.010 | 0.80 (0.56, 1.14) | 0.210 |
| >360 cDDD | 1.84 (1.45, 2.35) | <0.001 | 0.83 (0.64, 1.07) | 0.150 |
| Duration of aspirin (year) | ||||
| <1 | 1.00 (reference) | 1.00 (reference) | ||
| 1–2 | 17.38 (11.13, 27.16) | <0.001 | 8.33 (5.31, 13.08) | 0.000 |
| 2–3 | 10.62 (7.14, 15.81) | <0.001 | 5.09 (3.41, 7.61) | 0.000 |
| ≥3 | 0.94 (0.76, 1.15) | 0.530 | 0.54 (0.44, 0.68) | 0.000 |
| Duration of clopidogrel (year) | ||||
| <1 | 1.00 (reference) | 1.00 (reference) | ||
| 1–2 | 3.67 (2.07, 6.52) | <0.001 | 2.06 (1.15, 3.68) | 0.010 |
| 2–3 | 2.66 (1.37, 5.15) | <0.001 | 1.20 (0.61, 2.35) | 0.610 |
| Duration of dual agents (year) | ||||
| <1 | 1.00 (reference) | 1.00 (reference) | ||
| 1–2 | 19.89 (12.81, 30.87) | <0.001 | 8.07 (5.15, 12.64) | <0.001 |
| 2–3 | 11.56 (7.88, 16.96) | <0.001 | 4.89 (3.30, 7.24) | <0.001 |
| ≥3 | 0.95 (0.77, 1.17) | 0.630 | 0.50 (0.40, 0.62) | <0.001 |
cSHR: crude subhazard ratio; aSHR: adjusted subhazard ratio; 95% CI: 95% confidence interval; cDDD: cumulative daily defined dose.