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The administration of M2 macrophage exosomes improves angiogenesis post-SCI. The existence of blood vessels in the SC after SCI for 3 days was determined by CD31 (A). The number of the CD31+ cells (C). The protein levels of HIF-1α and VEGF were evaluated by WB. GAPDH expression was employed as an internal control (B,D,E). Mean ± SD. ** p < 0.01 SCI + saline group versus sham group, ## p < 0.01 SCI + Exo versus saline group. N = 5 per group. Scale bar = 50 µm.
