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. 2022 Oct 6;12(10):1430. doi: 10.3390/biom12101430

Table 1.

Anticholinesterase results of the isolated phytosteroids in comparison to galantamine.

Samples Concentration Percent AChE
(mean ± SEM)
AChE IC50
(μg/mL)
Percent BChE
(mean ± SEM)
BChE IC50
(μg/mL)
Compound 1 1000 85.72 ± 0.79 ns 20.29 84.83 ± 0.62 *** 27.35
500 77.68 ± 0.63 *** 80.76 ± 0.63 ***
250 71.46 ± 0.53 *** 75.70 ± 0.62 ***
125 64.78 ± 0.60 *** 66.65 ± 0.78 ***
62.5 55.56 ± 0.52 *** 59.81 ± 0.65 ***
Compound 2 1000 80.85 ± 0.18 *** 14.51 83.53 ± 0.20 *** 10.65
500 75.59 ± 0.30 *** 78.62 ± 0.17 ***
250 68.75 ± 0.14 *** 73.42 ± 0.11 ***
125 63.47 ± 0.49 *** 66.20 ± 0.15 ***
62.5 58.12 ± 0.34 *** 61.35 ± 0.18 ***
Galantamine 1000 87.81 ± 0.60 7.52 89.37 ± 0.64 5.53
500 82.74 ± 0.61 83.45 ± 0.65
250 77.68 ± 0.60 78.37 ± 0.54
125 72.63 ± 0.76 74.30 ± 0.61
62.5 65.79 ± 0.63 67.42 ± 0.55

Data are presented as (mean ± S.E.M); two-way ANOVA followed by Bonferroni test were followed. Values significantly different as compared to positive control; n = 3, *** = p < 0.001, ns; non-significant.