Table 1.
Samples | Concentration | Percent AChE (mean ± SEM) |
AChE IC50 (μg/mL) |
Percent BChE (mean ± SEM) |
BChE IC50 (μg/mL) |
---|---|---|---|---|---|
Compound 1 | 1000 | 85.72 ± 0.79 ns | 20.29 | 84.83 ± 0.62 *** | 27.35 |
500 | 77.68 ± 0.63 *** | 80.76 ± 0.63 *** | |||
250 | 71.46 ± 0.53 *** | 75.70 ± 0.62 *** | |||
125 | 64.78 ± 0.60 *** | 66.65 ± 0.78 *** | |||
62.5 | 55.56 ± 0.52 *** | 59.81 ± 0.65 *** | |||
Compound 2 | 1000 | 80.85 ± 0.18 *** | 14.51 | 83.53 ± 0.20 *** | 10.65 |
500 | 75.59 ± 0.30 *** | 78.62 ± 0.17 *** | |||
250 | 68.75 ± 0.14 *** | 73.42 ± 0.11 *** | |||
125 | 63.47 ± 0.49 *** | 66.20 ± 0.15 *** | |||
62.5 | 58.12 ± 0.34 *** | 61.35 ± 0.18 *** | |||
Galantamine | 1000 | 87.81 ± 0.60 | 7.52 | 89.37 ± 0.64 | 5.53 |
500 | 82.74 ± 0.61 | 83.45 ± 0.65 | |||
250 | 77.68 ± 0.60 | 78.37 ± 0.54 | |||
125 | 72.63 ± 0.76 | 74.30 ± 0.61 | |||
62.5 | 65.79 ± 0.63 | 67.42 ± 0.55 |
Data are presented as (mean ± S.E.M); two-way ANOVA followed by Bonferroni test were followed. Values significantly different as compared to positive control; n = 3, *** = p < 0.001, ns; non-significant.