Figure 4.

Six-week injury model comparison. Nerve microarchitecture is restored with intact perineurium in both injury types. Crush sites are not clearly identified in crush-only nerve, as markings were not clearly visible at time of sectioning. In the stretch–crush nerve, note the stained perineurial cells encompassing axons at injury site (insert), consistent with prior perineurium disruption (Figure 3e) and axonal regeneration intertwined with perineurial cell proliferation, findings consistent with an NIC injury. NIC, neuroma in continuity.