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. 2022 Sep 25;12(10):1293. doi: 10.3390/brainsci12101293

Figure 7.

Figure 7

TripleB cultured barriers demonstrate a much higher expression of P-glycoprotein along with other endothelial-cell-specific markers when compared to transwell-cultured barriers. Phenotypic differences in the static and dynamic cultured BBB (A) BBB cultured in the TripleB slides showed a significantly higher expression of EC-specific markers compared with the static in vitro BBB. (B) mRNA encoding the tight junction proteins SLC2A1, TJP1, OCLDN1 and CLDN5 was found to be significantly upregulated in TripleB cultures as compared to the static BBB cultures (n = 4, * p ≤ 0.05; ** p ≤ 0.01).