Figure 1.

OGG1 inhibition reduces acinar cell injury and inflammatory cell recruitment in cerulein-induced acute pancreatitis. The treatment protocol is presented on panel. Mice were injected i.p. with TH5487 or vehicle 1 h before induction of AP with 8 repeated cerulein injections. Blood and pancreata were collected 10 h after the first cerulein injection when animals were sacrificed (A). TH5487 markedly reduced serum amylase (B) and lipase levels (C) and suppressed leukocyte infiltration in the pancreas as indicated by decreased MPO levels (D). Values represent mean ± SD, n = 6. * p < 0.05 vs. control group, # p < 0.05 vs. cerulein group.