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TH5478 reduces nuclear PARylation in AP. Representative images of pancreatic sections immunostained for poly(ADP-ribose) polymers (A). Nuclear PAR formation increased in cerulein-treated mice compared to the controls. PAR levels were significantly reduced after TH5487 treatment. Quantitation of PAR immunofluorescence signals (B). Values are presented as mean ± SD, n = 6. * p < 0.05 vs. control group, # p < 0.05 vs. cerulein group. Scale bars are 50 µm.
