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. 2022 Oct 12;10(10):2543. doi: 10.3390/biomedicines10102543

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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OGG1 inhibition increase cell viability by promoting apoptosis and reducing necrosis. (A) OGG1 inhibition increased viability in primary acinar cells and reduced necrosis as shown by decreased LHD level (B) and Sytox Green intensity (C). OGG1 inhibition increased apoptosis in primary acinar cells (D), which correlates to the results of immunohistochemical staining of pancreas sections for cleaved PARP (E). (F) Cleaved PARP formation increased in cerulein-treated mice compared to the controls and increased significantly further in TH5487 treatment group. Data are presented as mean ± SD. * p < 0.05 vs. control group, # p < 0.05 vs. cerulein group.