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. 2022 Oct 12;10(10):2543. doi: 10.3390/biomedicines10102543

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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TH5487 prevents proinflammatory cytokine production in AP. Cytokine levels were measured with cytokine arrays from pancreas tissues obtained 10 h after the first cerulein injection. TH5487 markedly reduced the level of CCL2 (A). The relative expressions of cytokines and chemokines in pancreata were measured by qPCR. Cerulein caused a 190-fold increase in CCL2 mRNA level (B) and a 61-fold increase in IL1β mRNA level (C). The OGG1 inhibitor significantly suppressed both CCL2 and IL1 expressions (B,C). TH5487 also significantly reduced the expression of several other proinflammatory genes (D). qPCR data are presented as mean ± SD, n = 6. * p < 0.05 vs. control group, # p < 0.05 vs. cerulein group.

TH5487 prevents proinflammatory cytokine production in AP. Cytokine levels were measured with cytokine arrays from pancreas tissues obtained 10 h after the first cerulein injection. TH5487 markedly reduced the level of CCL2 (A). The relative expressions of cytokines and chemokines in pancreata were measured by qPCR. Cerulein caused a 190-fold increase in CCL2 mRNA level (B) and a 61-fold increase in IL1β mRNA level (C). The OGG1 inhibitor significantly suppressed both CCL2 and IL1 expressions (B,C). TH5487 also significantly reduced the expression of several other proinflammatory genes (D). qPCR data are presented as mean ± SD, n = 6. * p < 0.05 vs. control group, # p < 0.05 vs. cerulein group.