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. 2022 Oct 15;12(10):1487. doi: 10.3390/biom12101487

Figure 6.

Figure 6

The expression of NNMT was related to the EMT pathway. (a) GSEA analysis for differently expression mRNAs in OSCC tissues with NNMT expression in hallmark datasets. (b) Significant upregulation of EMT gene set in OSCC tissues with NNMT-high expression. (c) The expression levels of the six classical markers of EMT in the NNMT-high group were significantly higher than those in the NNMT-low group. (d) Heatmap shows the relationship between EMT-related genes and NNMT expression levels in OSCC tissues. (e) NNMT promotes tumor cell proliferation and migration through the EMT pathway. EMT, epithelialؘ–mesenchymal transition; GSEA, Gene Set Enrichment Analysis. ** and **** represented differences were considered statistically significant with p < 0.01 and p < 0.001, respectively.