Table 3.

Cox-regression analysis of DFS and MFS in OSCC patients.

Variables	Univariate Analysis						Multivariate Analysis
	Disease-Free Survival			Metastasis Free Survival			Disease-Free Survival			Metastasis Free Survival
	HR	95%CI	p Value	HR	95%CI	p Value	HR	95%CI	p Value	HR	95%CI	p Value
Gender
Male	1			1
Female	0.584	0.326–1.047	0.071	0.344	0.107–1.106	0.073
Age
<60	1			1
≥60	0.849	0.476–1.515	0.579	0.612	0.212–1.768	0.365
Smoking
No	1			1
Yes	1.000	0.527–1.896	1.000	2.076	0.715–6.032	0.179
T stage
I–II	1			1
III–IV	1.239	0.702–2.188	0.460	2.576	0.893–7.435	0.080
Lymph node metastasis
No	1			1
Yes	2.335	1.321–4.129	0.004 *	3.904	1.213–12.571	0.022 *	1.556	0.821–2.949	0.176
Chemoradiotherapy
No	1			1
Yes	1.866	1.069–3.258	0.028 *	2.932	0.980–8.770	0.054	1.000	0.531–1.886	0.999
Differentiation
Well	1			1
Moderate/poor	1.414	0.535–2.437	0.733	1.400	0.312–6.278	0.660
DOI
<5 mm	1			1
≥5 mm	2.735	1.464–5.111	0.002 *	1.686	0.560–5.074	0.353	2.306	1.152–4.616	0.018 *
WPOI
I–III	1			1
IV–V	2.596	1.423–4.640	0.002 *	2.245	0.745–6.765	0.151	1.344	0.657–2.750	0.419
NNMT in TCs
Low	1			1
High	2.263	1.287–3.979	0.005 *	2.221	0.767–6.427	0.141	2.104	1.155–3.833	0.015 *

HR, hazard ratio; CI, confidence interval; * represented differences were considered statistically significant with p < 0.05.