Table 1.

Mitophagy in IVDD.

Authors	Potential Targets	Cells	Signaling	Mitophagy	Function
Xie et al. [76]	CircERCC2	NPCs	miR-182-5p/SIRT1	Promoting	Alleviating IVDD
Wang et al. [77]	Moderate mechanical stress	NPCs	SIRT1-PINK1	Promoting	Alleviating IVDD
Xu et al. [19]	SIRT2	AF cells	SIRT2/PGC-1α	Inhibiting	Alleviating IVDD
Hu et al. [78]	/	NPCs	Nrf2/Sirt3	Promoting	Alleviating IVDD
Wang et al. [79]	honokiol	NPCs	AMPK/PGC-1α/SIRT3	Promoting	Alleviating IVDD
Lin et al. [80]	Urolithin A	NPCs	AMPK	Promoting	Alleviating IVDD
Wang et al. [81]	PINK1	NPCs	PINK1/Parkin	Promoting	Alleviating IVDD
Ma et al. [82]	SIRT1	NPCs	PINK1/Parkin	Promoting	Alleviating IVDD
Kang et al. [83]	MitoQ	NPCs	PINK1/Parkin	Promoting	Alleviating IVDD
Chen et al. [84]	Mfn2	NPCs	PINK1/Parkin	Inhibiting	Aggravating IVDD
Wang et al. [85]	MIF	NPCs	PINK1/Parkin	Promoting	Alleviating IVDD
Huang et al. [86]	Excessive mechanical stress	NPCs	PINK1/Parkin	Promoting	Aggravating IVDD
Lan et al. [87]	/	NPCs	Parkin	Promoting	Alleviating IVDD
Lin et al. [88]	LRRK2	NPCs	Parkin	Promoting	Alleviating IVDD
Chen et al. [89]	Melatonin	NPCs	Parkin	Promoting	Alleviating IVDD
Kang et al. [90]	/	Endplate chondrocyte	Parkin	Promoting	Alleviating IVDD
Zhang et al. [91]	Salidroside	NPC	Parkin	Promoting	Alleviating IVDD
Madhu et al. [28]	HIF-1	NPC	HIF-1α-BNIP3	Promoting	Alleviating IVDD
Xu et al. [92]	/	NPC	HIF-1α/NDUFA4L2	Promoting	Aggravating IVDD