Figure 2.

Phylogenetic tree and domain structure of DUBs in S. cerevisiae, C. neoformans, and M. oryzae: (A) Phylogenetic tree and domain structures of ubiquitin-specific proteases (UBPs) (zf-UBP, Zn-finger in ubiquitin-hydrolases and other protein; UBA, ubiquitin associated domain; RPT, repeated domain in UCH-protein; UBL, ubiquitin-like domain; DUSP, domain present in ubiquitin-specific protease; MATH, meprin and TRAF homology; USP7_C2, ubiquitin-specific protease C-terminal; USP7_ICP0_bdg, ICP0-binding domain of ubiquitin-specific protease 7); (B) phylogenetic tree and domain structures of UCHs, OTUs, MINDY, and JAMM family proteins. The domain architectures of DUBs are drawn by referring to predicted results from databases of Pfam, PROSITE, SMART, and Interpro.