Table 3.
Comparison of changes in tortuosity in observation and chronic RBC transfusion arms.
| Chronic Transfusion Therapy (n = 5) | Observation Only (n = 5) | p-Value | ||||
|---|---|---|---|---|---|---|
| Tortuosity Index Mean (SD) | Mean Change in Tortuosity Index (SD) | Tortuosity Index Mean (SD) | Mean Change in Tortuosity Index (SD) | |||
| Pre-randomization | right | 0.85 (0.45) | 0.90 (0.30) | 0.84 + | ||
| left | 0.87 (0.46) | 0.60 (0.17) | 0.25 + | |||
| 36 Month | right | 0.99 (0.18) | 0.15 (0.30) | 0.92 (0.42) | 0.02 (0.27) | 0.49 ++ |
| left | 0.82 (0.18) | −0.04 (0.34) | 0.70 (0.26) | 0.10 (0.21) | 0.46 ++ | |
+ = two tailed p-value for pre-randomization tortuosity in the observation group vs. the cRBC group. ++ = two tailed p-value for mean change in tortuosity in the observation group vs. the cRBC group. cRBC = chronic blood transfusion, SD = standard deviation.