Figure 2.

Graphical representation of epigenetic events potentially involved in the initiation and development of the tumors, including uterine LMS and ESS. The biogenesis of miRNAs starts in the nucleus and ends in the cytoplasm. This process includes the participation of several enzymes and protein complexes that regulate the production of mature molecules capable of regulating gene expression, both through induction of mRNA degradation and translational repression. Likewise, dynamic alterations of histone modifications, including acetylation, methylation, and phosphorylation, modify gene expression, thus affecting DNA replication and repair, chromatin compaction, and cell cycle control. In addition, histone modification readers such as BRDs can recognize modified histones, therefore altering gene expression and responding to different signals. Dysregulation in the epigenetic machinery leads to malignant transformation of cells culminating in the development of cancer. Created with BioRender.com.