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. 2022 Oct 13;10(10):2567. doi: 10.3390/biomedicines10102567

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Schematic representation of the DNA methylation process in LMS and ESS during cancer development and progression. Methyl groups are added to the DNA molecule and change its activity. Promoter hypermethylation has been shown to silence tumor suppressor genes in cancer cells, leading to either dysregulation of cell growth or inducing resistance to cancer therapies. Hypomethylation promotes genomic instability causing missegregation of chromosomes during cell division. Created with BioRender.com.