Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 13;10(10):2567. doi: 10.3390/biomedicines10102567

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Chromatin remodeling process in LMS and ESS. Chromatin remodeling is an important mechanism of gene expression regulation. In the histone acetylation induced by HATs, the condensed chromatin is transformed into a more relaxed structure (euchromatin) that is associated with greater levels of gene transcription, while histone hypoacetylation induced by HDAC activity is associated with more condensed chromatin (heterochromatin), inducing gene silencing. Altered expression and mutations of genes that encode HDACs have been linked to tumor development. Created with BioRender.com.