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. 2022 Oct 13;10(10):2567. doi: 10.3390/biomedicines10102567

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Graphical representation of the ncRNAs dysregulation in LMS and ESS. ncRNAs have been identified as oncogenic drivers or tumor suppressors in cancer. LncRNAs often affect the expression of their target genes by interacting with miRNAs, which are the main post-transcriptional regulation factors. Some lncRNAs act like sponges, thereby preventing miRNAs from binding to their target mRNAs. As lncRNAs work as decoys for miRNAs, oncogene mRNA translation is allowed, starting the LMS and ESS carcinogenesis. Created with BioRender.com.