Table 2.
Molecular features of endometrial stromal tumors (ESTs).
| Category EST | Fusion/Gene Alteration [72,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101] |
|---|---|
| Endometrial Stromal Nodule (ESN) |
JAZF1-SUZ121 [86,87] MEAF6-PHF1 [86,87] |
| Low-Grade Endometrial Stromal Sarcoma (LG-ESS) |
JAZF1-SUZ121 [88] JAZF1-PHF1 [88] MEAF6-PHF1 [88] EPC1-PHF1 [89] MBTD1-EZHIP [89] JAZF1-BCORL1 [89] MAGED2-PLAG1 [90] MEAF6-SUZ12 [91] EPC2-PHF1 [92] BRD8-PHF1 [72] EPC1-BCOR [72] EPC1-SUZ12 [72] |
| High-Grade Endometrial Stromal Sarcoma (HG-ESS) |
YWHAE-NUTM2A/B1 [93] BCOR-rearrangement [94] ZC3H7B-BCOR [72,95] EPC1-BCOR [96] EPC1-SUZ12 [96] BCOR-ITD [72] LPP-BCOR [72] BRD8-PHF1 [97] |
| Undifferentiated Uterine Sarcoma (UUS) |
JAZF1-SUZ12 [97] YWHAE-NUTM2 [97] ZC3H7B-BCOR [97] YWHAE-rearrangement [97] HMGA-RAD51B [98] SMARCA4-deficient [99] |
| NTRK-Rearranged Uterine Sarcomas (HG-ESS) |
RBPMS-NTRK3 [100,101] TPR-NTRK1 [100,101] LMNA-NTRK1 [100,101] TPM3-NTRK1 [100,101] EML4-NTRK3 [100,101] STRN-NTRK3 [100,101] |
1 Most common alterations.