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Preparation of Fab x sdAb-Fc TbsAbs with different hinge designs. (A) Schematic diagrams of two types of Fab x sdAb-Fc TbsAbs: TbsAb.long, TbsAb.short. (B) Schematic illustration of mCD3E × mEGFR TbsAbs generated by the duobody platform. (C) Schematic diagrams of tumor cell eliminated by mCD3E × mEGFR TbsAbs.
