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Inhibition of PHGDH radiosensitizes human hypoxic colorectal cancer cells through excessive ROS. HCT116 (top) and DLD-1 (bottom) cells were treated with NCT-503 (16 h) at indicated concentrations, irradiated and reseeded for colony formation assay. (A) Dose–response curves under normoxic (B) and hypoxic conditions. (C) Dose–response curve under hypoxic conditions with treatment of 60 μM NCT-503 with the addition of NAC.
