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. 2022 Oct 21;12(10):1532. doi: 10.3390/biom12101532

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Activities of the respiratory chain complexes in the retinal pigment epithelial cells (RPE) of the minipig eyes after acute high intraocular pressure-induced retinal ischemia. Increased complex I and mildly increased complex IV (A) and mildly decreased complex III activity (B) were detected in diseased RPE cells in comparison to controls. Activities of the respiratory chain complexes were measured spectrophotometrically in homogenate, normalized values to citrate synthase are shown. I—respiratory chain complex I, NADH: ubiquinone oxidoreductase; II—complex II, succinate: coenzyme Q reductase; III—complex III, ubiquinol: cytochrome c oxidoreductase; IV—complex IV, cytochrome c oxidase; I + III, complex I + III, NADH: cytochrome c reductase; II + III, complex II + III, succinate: cytochrome c reductase. C—control eye, D—eye after acute intraocular pressure elevation. n = 3. Each sample was analyzed in doublets.