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. 2022 Oct 12;12(10):862. doi: 10.3390/bios12100862

Figure 9.

Figure 9

(a) A series of SPR sensors modified with different SARS-CoV-2 antigens (nucleocapsid, RBD, or spike) is applied to detect human antibodies from different blood products (serum, plasma, or dried blood spots) collected from COVID-positive or -negative individuals. Reprinted with permission from ref. [108]. (b) Label-free FO-SPR serological bioassays with sandwich formats for the detection of anti-SARS-CoV-2 RBD antibodies. Reprinted with permission from ref. [110]. Copyright 2022, American Chemical Society. (c) Schematic diagram of the fast wavelength interrogation SPR imaging biosensors. Reprinted with permission from ref. [111]. Copyright 2021, American Chemical Society. (d) Schematic of the five-channel SPR system with an autosampler for detecting the anti-SARS-CoV-2 antibody in serum samples (left). Captures of the anti-SARS-CoV-2 antibody by the His-tagged S1 protein pre-immobilized onto the CM-dextran-based tris-NTA sensor (right). Reprinted with permission from ref. [112]. Copyright 2022, Elsevier.