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. 2022 Oct 14;14(20):5020. doi: 10.3390/cancers14205020

Figure 1.

Figure 1

Endometrial serous carcinoma (ESC) with its classic immuno- and molecular profile. ESC shows deep myometrial invasion (upper left) and striking nuclear atypia in a high-power view (upper mid). Immunohistologically, the tumor shows mutant p53 (upper right), loss of ER/PR expression (lower left), proficient MMR panel (lower mid), and 3+ Her2/neu overexpression. By sequencing analysis, the tumor shows no POLE ultramutation (not shown). Molecular classification: TCGA group 4, p53 aberrant type.