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. 2022 Oct 18;14(20):5090. doi: 10.3390/cancers14205090

Figure 3.

Figure 3

Anti-miR-214 treatment reverted the inflammatory phenotype induced in RAW 264.7 by melanoma-derived acid EV. (A) Real-time qPCR of IL-1β, IL-6, and TNF-α mRNA expression in RAW.264.7 treated with acid-EV derived from B16, B16-LU, or B16-LI cells in the presence or absence of anti-miR-214-3p/5p (a-miR). (B) ELISA for IL-1β, IL-6, and TNF-α production by RAW 264.7 treated with acid-EV in the presence or absence of anti-miR-214-3p/5p. (A,B) All conditions were found different (p < 0.005; one-way ANOVA) from the untreated (UT). (C) NO production by RAW 264.7 macrophages treated with acid EV in the presence or absence of anti-miR-214-3p/5p (one-way ANOVA; * p < 0.05, and *** p < 0.001).