Table 1.
Upk3 immunostaining in human tumors. int. = interpretable, neg. = negative, mod. = moderate, str. = strong.
| Upk3b Immunostaining Result | |||||||
|---|---|---|---|---|---|---|---|
| Tumor Entity | on TMA (n) | int. (n) | neg. (%) | weak (%) | mod. (%) | str. (%) | |
| Tumors of the skin | Pilomatrixoma | 35 | 33 | 100.0 | 0.0 | 0.0 | 0.0 |
| Basal cell carcinoma | 89 | 79 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Benign nevus | 29 | 28 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Squamous cell carcinoma of the skin | 145 | 142 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Malignant melanoma | 65 | 62 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Malignant melanoma lymph node metastasis | 86 | 78 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Merkel cell carcinoma | 48 | 43 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Tumors of the head and neck | Squamous cell carcinoma of the larynx | 109 | 107 | 100.0 | 0.0 | 0.0 | 0.0 |
| Squamous cell carcinoma of the pharynx | 60 | 59 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Oral squamous cell carcinoma (floor of the mouth) | 130 | 129 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Pleomorphic adenoma of the parotid gland | 50 | 49 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Warthin tumor of the parotid gland | 104 | 104 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Adenocarcinoma, NOS (Papillary Cystadenocarcinoma) | 14 | 13 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Salivary duct carcinoma | 15 | 15 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Acinic cell carcinoma of the salivary gland | 181 | 160 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Adenocarcinoma NOS of the salivary gland | 109 | 92 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Adenoid cystic carcinoma of the salivary gland | 180 | 116 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Basal cell adenocarcinoma of the salivary gland | 25 | 23 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Basal cell adenoma of the salivary gland | 101 | 96 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Epithelial-myoepithelial carcinoma of the salivary gland | 53 | 53 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Mucoepidermoid carcinoma of the salivary gland | 343 | 307 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Myoepithelial carcinoma of the salivary gland | 21 | 21 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Myoepithelioma of the salivary gland | 11 | 10 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Oncocytic carcinoma of the salivary gland | 12 | 12 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Polymorphous adenocarcinoma, low grade, of the salivary gland | 41 | 37 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Pleomorphic adenoma of the salivary gland | 53 | 43 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Tumors of the lung, pleura, and thymus | Adenocarcinoma of the lung | 196 | 184 | 100.0 | 0.0 | 0.0 | 0.0 |
| Squamous cell carcinoma of the lung | 80 | 75 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Small cell carcinoma of the lung | 16 | 16 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Mesothelioma, epithelioid | 40 | 28 | 17.9 | 25.0 | 14.3 | 42.9 | |
| Mesothelioma, biphasic | 77 | 52 | 69.2 | 11.5 | 5.8 | 13.5 | |
| Thymoma | 29 | 29 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Tumors of the female genital tract | Squamous cell carcinoma of the vagina | 78 | 73 | 100.0 | 0.0 | 0.0 | 0.0 |
| Squamous cell carcinoma of the vulva | 157 | 147 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Squamous cell carcinoma of the cervix | 136 | 129 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Adenocarcinoma of the cervix | 23 | 23 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Endometrioid endometrial carcinoma | 338 | 296 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Endometrial serous carcinoma | 86 | 75 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Carcinosarcoma of the uterus | 57 | 44 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Endometrial carcinoma, high grade, G3 | 13 | 11 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Endometrial clear cell carcinoma | 9 | 9 | 88.9 | 11.1 | 0.0 | 0.0 | |
| Endometrioid carcinoma of the ovary | 130 | 108 | 99.1 | 0.9 | 0.0 | 0.0 | |
| Serous carcinoma of the ovary | 580 | 539 | 89.4 | 8.7 | 1.7 | 0.2 | |
| Mucinous carcinoma of the ovary | 101 | 81 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Clear cell carcinoma of the ovary | 51 | 42 | 97.6 | 2.4 | 0.0 | 0.0 | |
| Carcinosarcoma of the ovary | 47 | 39 | 97.4 | 2.6 | 0.0 | 0.0 | |
| Granulosa cell tumor of the ovary | 44 | 43 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Leydig cell tumor of the ovary | 4 | 4 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Sertoli cell tumor of the ovary | 1 | 1 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Sertoli Leydig cell tumor of the ovary | 3 | 3 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Steroid cell tumor of the ovary | 3 | 3 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Brenner tumor | 41 | 37 | 89.2 | 10.8 | 0.0 | 0.0 | |
| Tumors of the breast | Invasive breast carcinoma of no special type | 499 | 472 | 100.0 | 0.0 | 0.0 | 0.0 |
| Lobular carcinoma of the breast | 192 | 168 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Medullary carcinoma of the breast | 23 | 22 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Tubular carcinoma of the breast | 20 | 17 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Mucinous carcinoma of the breast | 29 | 27 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Phyllodes tumor of the breast | 50 | 41 | 100.0 | 0.0 | 0.0 | 0.0 | |
|
Tumors of the digestive
system |
Adenomatous polyp, low-grade dysplasia | 50 | 50 | 100.0 | 0.0 | 0.0 | 0.0 |
| Adenomatous polyp, high-grade dysplasia | 50 | 48 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Adenocarcinoma of the colon | 2483 | 2392 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Gastric adenocarcinoma, diffuse type | 215 | 210 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Gastric adenocarcinoma, intestinal type | 215 | 204 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Gastric adenocarcinoma, mixed type | 62 | 60 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Adenocarcinoma of the esophagus | 83 | 81 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Squamous cell carcinoma of the esophagus | 76 | 66 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Squamous cell carcinoma of the anal canal | 91 | 87 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Cholangiocarcinoma | 58 | 56 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Gallbladder adenocarcinoma | 51 | 50 | 98.0 | 0.0 | 0.0 | 2.0 | |
| Gallbladder Klatskin tumor | 42 | 42 | 95.2 | 2.4 | 2.4 | 0.0 | |
| Hepatocellular carcinoma | 312 | 294 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Ductal adenocarcinoma of the pancreas | 659 | 641 | 99.5 | 0.5 | 0.0 | 0.0 | |
| Pancreatic/Ampullary adenocarcinoma | 98 | 93 | 97.8 | 2.2 | 0.0 | 0.0 | |
| Acinar cell carcinoma of the pancreas | 18 | 17 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Gastrointestinal stromal tumor (GIST) | 62 | 60 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Tumors of the urinary system | Non-invasive papillary urothelial carcinoma, pTa G2 low grade | 177 | 116 | 54.3 | 44.0 | 1.7 | 0.0 |
| Non-invasive papillary urothelial carcinoma, pTa G2 high grade | 141 | 104 | 60.6 | 34.6 | 3.8 | 1.0 | |
| Non-invasive papillary urothelial carcinoma, pTa G3 | 219 | 155 | 65.8 | 32.9 | 0.6 | 0.6 | |
| Urothelial carcinoma, pT2-4 G3 | 735 | 608 | 85.4 | 10.7 | 2.3 | 1.6 | |
| Squamous cell carcinoma of the bladder | 22 | 22 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Small cell neuroendocrine carcinoma of the bladder | 23 | 23 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Sarcomatoid urothelial carcinoma | 25 | 24 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Urothelial carcinoma of the kidney pelvis | 62 | 54 | 85.2 | 11.1 | 1.9 | 1.9 | |
| Clear cell renal cell carcinoma | 1287 | 1148 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Papillary renal cell carcinoma | 368 | 323 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Clear cell (tubulo) papillary renal cell carcinoma | 26 | 24 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Chromophobe renal cell carcinoma | 170 | 143 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Oncocytoma | 257 | 217 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Tumors of the male genital organs | Adenocarcinoma of the prostate, Gleason 3+3 | 83 | 83 | 100.0 | 0.0 | 0.0 | 0.0 |
| Adenocarcinoma of the prostate, Gleason 4+4 | 80 | 75 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Adenocarcinoma of the prostate, Gleason 5+5 | 85 | 84 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Adenocarcinoma of the prostate (recurrence) | 258 | 249 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Small cell neuroendocrine carcinoma of the prostate | 19 | 18 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Seminoma | 682 | 653 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Embryonal carcinoma of the testis | 54 | 43 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Leydig cell tumor of the testis | 31 | 29 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Sertoli cell tumor of the testis | 2 | 2 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Sex cord stromal tumor of the testis | 1 | 1 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Spermatocytic tumor of the testis | 1 | 1 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Yolk sac tumor | 53 | 43 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Teratoma | 53 | 18 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Squamous cell carcinoma of the penis | 92 | 86 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Tumors of endocrine organs | Adenoma of the thyroid gland | 113 | 111 | 100.0 | 0.0 | 0.0 | 0.0 |
| Papillary thyroid carcinoma | 391 | 372 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Follicular thyroid carcinoma | 154 | 153 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Medullary thyroid carcinoma | 111 | 109 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Parathyroid gland adenoma | 43 | 35 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Anaplastic thyroid carcinoma | 45 | 42 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Adrenal cortical adenoma | 50 | 38 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Adrenal cortical carcinoma | 28 | 28 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Phaeochromocytoma | 50 | 50 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Appendix, neuroendocrine tumor (NET) | 25 | 19 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Colorectal, neuroendocrine tumor (NET) | 12 | 10 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Ileum, neuroendocrine tumor (NET) | 53 | 51 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Lung, neuroendocrine tumor (NET) | 29 | 29 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Pancreas, neuroendocrine tumor (NET) | 101 | 93 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Colorectal, neuroendocrine carcinoma (NEC) | 14 | 13 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Ileum, neuroendocrine carcinoma (NEC) | 8 | 8 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Gallbladder, neuroendocrine carcinoma (NEC) | 4 | 4 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Pancreas, neuroendocrine carcinoma (NEC) | 14 | 13 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Tumors of haemotopoetic and lymphoid tissues | Hodgkin Lymphoma | 103 | 101 | 100.0 | 0.0 | 0.0 | 0.0 |
| Small lymphocytic lymphoma, B-cell type (B-SLL/B-CLL) | 50 | 49 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Diffuse large B cell lymphoma (DLBCL) | 113 | 109 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Follicular lymphoma | 88 | 84 | 100.0 | 0.0 | 0.0 | 0.0 | |
| T-cell non-Hodgkin lymphoma | 25 | 25 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Mantle cell lymphoma | 18 | 18 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Marginal zone lymphoma | 16 | 15 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Diffuse large B-cell lymphoma (DLBCL) in the testis | 16 | 16 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Burkitt lymphoma | 5 | 4 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Tumors of soft tissue and bone | Tendosynovial giant cell tumor | 45 | 45 | 100.0 | 0.0 | 0.0 | 0.0 |
| Granular cell tumor | 53 | 44 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Leiomyoma | 50 | 50 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Leiomyosarcoma | 94 | 93 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Liposarcoma | 145 | 139 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Malignant peripheral nerve sheath tumor (MPNST) | 15 | 15 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Myofibrosarcoma | 26 | 26 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Angiosarcoma | 74 | 67 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Angiomyolipoma | 91 | 91 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Dermatofibrosarcoma protuberans | 21 | 19 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Ganglioneuroma | 14 | 13 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Kaposi sarcoma | 8 | 6 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Neurofibroma | 117 | 99 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Sarcoma, not otherwise specified (NOS) | 74 | 72 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Paraganglioma | 41 | 40 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Ewing sarcoma | 23 | 20 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Rhabdomyosarcoma | 7 | 7 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Schwannoma | 122 | 112 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Synovial sarcoma | 12 | 11 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Osteosarcoma | 44 | 39 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Chondrosarcoma | 40 | 27 | 100.0 | 0.0 | 0.0 | 0.0 | |
| Rhabdoid tumor | 5 | 5 | 100.0 | 0.0 | 0.0 | 0.0 | |