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. 2022 Oct 14;11(20):3230. doi: 10.3390/cells11203230

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Changes in adipose tissue during obesity. (A) Adipose tissue of normal-weight individuals, (B) changes in adipose tissue occurring in obesity. During obesity, adipose tissue expansion occurs, characterized mainly by adipocyte hypertrophy. At the cellular level, a change in the secretory profile of adipokines has been reported, highlighting a decrease in adiponectin and an increase in leptin, resistin, apelin, and visfatin. The four short isoforms contain a conserved box1 motif involved in JAK2 recruitment.